Noggin murine rec.
Product number:
CB-1600020
Manufacturer product number:
CB-1600020
Delivery time:
4-5 weeks
Min. order quantity:
1
Product information "Noggin murine rec."
Noggin is a secreted polypeptide, which is encoded by the NOG gene. It binds and inactivates members of the TGF-beta (transforming growth factor-beta) super family signaling proteins, like the BMP4 (bone morphogenetic protein-4). It is suggested, that noggin plays a critical role in creating a morphogenetic gradient of the TGF-beta super family.
It appears, that Noggin has a peiotropic effect, as well in early as in later stages of the development. Its first isolation was from Xenopus, because of its inhibitory action of BMP4, and thus its ability to restore a normal dorsal-ventral body axis in artificially (by UV treatment) ventralized embryos. The results of mouse knock out of noggin show that it is involved in numerous developmental processes such as neutral tube fusion and joint formation. Heterozygous missense mutations in the noggin gene can cause deformities such as joint fusions and syndromes such as SYNS1 (multiple synostosis syndrome) and SYM1 (proximal symphalangism). Noggin mouse rec. is a non-glycolysated in E-coli, and has a total molecular weight of approximately 46.2 kDa. It is purified by proprietary chromatographic techniques.
Synonyms: Noggin, SYM1, SYN1, NOG
It appears, that Noggin has a peiotropic effect, as well in early as in later stages of the development. Its first isolation was from Xenopus, because of its inhibitory action of BMP4, and thus its ability to restore a normal dorsal-ventral body axis in artificially (by UV treatment) ventralized embryos. The results of mouse knock out of noggin show that it is involved in numerous developmental processes such as neutral tube fusion and joint formation. Heterozygous missense mutations in the noggin gene can cause deformities such as joint fusions and syndromes such as SYNS1 (multiple synostosis syndrome) and SYM1 (proximal symphalangism). Noggin mouse rec. is a non-glycolysated in E-coli, and has a total molecular weight of approximately 46.2 kDa. It is purified by proprietary chromatographic techniques.
Synonyms: Noggin, SYM1, SYN1, NOG
Properties "Noggin murine rec."
| Liquid / Powder: | Powder |
|---|---|
| Product Category: | Cytokines and Growth Factors |
| Size: | 20 µg |
| Sterile: | Yes |
| Storage: | See Datasheet |
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